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Pivanex
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pivanex图片
CAS NO:122110-53-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
AN-9
Pivalyloxymethyl butyrate
产品介绍
Pivanex 是丁酸的一种衍生物,是具有口服活性的HDAC抑制剂。Pivanex通过下调Bcr-Abl蛋白增强凋亡。Pivanex显示出抗转移和抗血管生成的活性。

产品描述

Pivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.

体外活性

Pivanex has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Pivanex (200 μM) causes enhancement in the G2-M phase, moderate enhancement in the S phase, and a slight reduction in G0-G1 of the cell cycle. Pivanex (100-500 μM) shows significant anti-proliferation activity in K562 cells. Pivanex (100-500 μM) also increases apoptosis and caspase activity in K562 cells [1][2].

体内活性

Pivanex treatment also marked delays in the end stage of disease as defined by the onset of body mass loss. Pivanex (200 mg/kg, b.i.d, daily) obviously improves the survival of SMN7 SMA mice [3].

Cas No.

122110-53-6

分子式

C10H18O4

分子量

202.25

别名

AN-9;Pivalyloxymethyl butyrate

储存和溶解度

DMSO:100 mg/mL (494.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years