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(±)-Zanubrutinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)-Zanubrutinib图片
CAS NO:1633350-06-7
包装:100 mg
市场价:9401元

产品名称
(±)-BGB-3111
(±)-赞鲁替尼
产品介绍

产品描述

(±)-Zanubrutinib is a specific, potent and orally available Btk inhibitor.

体外活性

In both biochemical and cellular assays, (±)-Zanubrutinib demonstrates nanomolar Btk inhibition activity. In comparison with ibrutinib, (±)-Zanubrutinib shows much more restricted off-target activities against a panel of kinases, including ITK. In several MCL and DLBCL cell lines, (±)-Zanubrutinib inhibits BCR aggregation-triggered Btk autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation.

体内活性

(±)-Zanubrutinib induces dose-dependent anti-tumor effects against REC-1 MCL xenografts engrafted either subcutaneously or systemically via tail vein injection in mice. In the subcutaneous xenografts. Preliminary 14-day toxicity study in rats shows that (±)-Zanubrutinib is a very well tolerated and maximally tolerated dose (MTD) is not reached when it is dosed up to 250mg/kg/day.

Cas No.

1633350-06-7

分子式

C27H29N5O3

分子量

471.55

别名

(±)-BGB-3111;(±)-赞鲁替尼

储存和溶解度

DMSO:28 mg/mL (59.38 mM)
Ethanol:10 mg/mL (21.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years