G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthritis.

G-744 (6.25/12.25/25 mg/kg, p.o., b.i.d., daily) treatment can prevent Lewis rats from collagen-induced arthritis, as a dose-dependently.

1346669-54-2

C29H29N5O3S

527.64

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years