ONO-4059 analog 是 ONO-4059 的类似物，ONO-4059 是一种高效、选择性的口服 BTK 抑制剂，IC50 为 23.9 nM。

ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.

In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio. [1]

1351635-67-0

C25H24N6O3

456.506

ONO-WG-307;ONO-4059 analogue;GS-4059 analog

H2O:<1 mgml
DMSO:16 mg/mL (35 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years