Heparan sulfate是一种复杂的线性多糖。Heparan sulfate作为硫酸乙酰肝素蛋白聚糖的一部分出现，在细胞外基质和细胞表面表达丰富。

Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to the maintenance of morphogen gradients and co-receptor functions [1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions [2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating the regeneration of small intestinal crypts after epithelial injury [3].

FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate [5]. Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning [4].

9050-30-0

C12H19NO20S3 (monomer)

593.47 (monomer)

硫酸类肝素;硫酸乙酰肝素

H2O:100 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years