FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，具有抗肿瘤的活性，对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的IC50值分别为 2.47、0.85、1.96 和 0.28 nM。

FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.

FN-1501 displays potent inhibitory activity against several tumor cells, such as MGC803, RS4;11, MCF-7, HCT-116, and NCI-H82 (GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively)[1].

FN-1501 shows potent antitumor activity and it also shows little cytotoxicity on normal lymphocyte cells (LD50: 185.67 mg/kg in ICR mice). FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and obviously inhibits the growth of tumors in MV4-11-cell-inoculated-xenograft mice[1].

1429515-59-2

C22H25N9O

431.49

DMSO:45 mg/mL (104.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years