UNC2025 2HCl (1429881-91-3(free base)) 是一种有效且具有口服生物利用度的 Mer/FLT3 双重抑制剂，对 Mer/FLT3 的 IC50 为 0.8/0.74 nM。

UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.

UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.

T4419

C28H42Cl2N6O

549.62

DMSO:6.66 mg/mL,Need ultrasonic; in vivo:dissolved in DMSO and then diluted with water (DMSO:water=1:6)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years