HPK1-IN-2 dihydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2056122-11-1

包装与价格：

包装	价格(元)
1 mg	电议
5 mg	电议
10 mg	电议
25 mg	电议
50 mg	电议
100 mg	电议

产品名称

Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2
HPK1-IN-2

产品介绍

HPK1-IN-2 是一种有效且具有口服活性的造血祖细胞激酶-1 抑制剂（HPK1；IC50<0.05 μM）。它还抑制 Lck (0.05 μM

产品描述

HPK1-IN-2 dihydrochloride is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1;IC50<0.05 μΜ). It also inhibits Lck (0.05 μΜ

体外活性

In a-CD3 stimulated Jurkat E6. 1 cells, HPK1-IN-2 inhibits SLP76 serine 376 phosphorylation and ERK1/2 T202/Y204 phosphorylation with IC50 values of 0.3-1 μΜ and >3μΜ, respectively.

体内活性

HPK1-IN-2 (75-150 mg/kg; oral gavage; daily; for 21 days) treatment shows a dose-dependently tumor growth inhibition, with 75 mg/kg and 150 mg/kg QD inhibiting tumour growth by 44% and 64%, respectively

Cas No.

2056122-11-1

分子式

C19H20N6OS

分子量

380.47

别名

Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2;HPK1-IN-2

储存和溶解度

H2O:25 mg/mL (55.14 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years