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Allitinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Allitinib图片
CAS NO:897383-62-9
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ALS 1306
AST-1306
产品介绍
Allitinib 是可口服的EGFR和ErbB2不可逆抑制剂,IC50分别为 0.5 和 3 nM。它具有抗癌活性,抑制ErbB4,IC50为 0.8 nM。

产品描述

Allitinib (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]

体外活性

AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibit the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. AST1306 inhibits the activation of tyrosine kinases and downstream signaling pathways in A549 cells, Calu-3 cells and SK-OV-3 cells,and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1].

体内活性

AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1].

Cas No.

897383-62-9

分子式

C24H18ClFN4O2

分子量

448.88

别名

ALS 1306;AST-1306

储存和溶解度

DMSO:20mg/mL (44.56mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years