EGFR-IN-7 是一种有效选择性的EGFR激酶抑制剂,对 EGFR (WT) 和 EGFR (mutant C797S/T790M/L858R) 的IC50值分别为 7.92 和 0.218 nM,具有抗肿瘤活性,详细信息请参考专利 WO2019015655A1。
产品描述
EGFR-IN-7 is a selective and potent EGFR kinase inhibitor.
体外活性
TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib.?It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively.
Cas No.
2267329-76-8
分子式
C32H41BrN9O2P
分子量
694.61
别名
TQB3804
储存和溶解度
DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years