Poziotinib hydrochloride 不可逆地抑制 EGFR（HER1 或 ErbB1），包括 EGFR 突变体、HER2 和 HER4，从而抑制过度表达这些受体的肿瘤细胞的增殖。它是一种口服生物可利用的、基于喹唑啉的泛表皮生长因子受体（EGFR 或 HER）抑制剂，具有潜在的抗肿瘤活性。

Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

1429757-68-5

C23H22Cl3FN4O3

527.8

波齐替尼盐酸盐;NOV120101 hydrochloride;HM 781-36B hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years