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Adenosine amine congener
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine amine congener图片
CAS NO:96760-69-9
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ADAC
产品介绍
AdeNOSine amine congener 是一种选择性的 A1 腺苷受体激动剂,具有神经保护作用,可以改善噪音和顺铂引起的耳蜗损伤。

产品描述

Adenosine amine congener (ADAC) is an agonist of selective A1 adenosine receptor,.

体内活性

Adenosine amine congener (ADAC) was most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection (averaged across 8-28 kHz). Pharmacokinetic studies demonstrated a short (5 min) half-life of ADAC in plasma after intravenous administration without detection of degradation products.

动物实验

Adenosine amine congener (ADAC)??(25-300 μg/kg) was administered intraperitoneally to Wistar rats (8-10 weeks old) at intervals (6-72 hours) after exposure to traumatic noise (8-16 kHz, 110 dB sound pressure level, 2 hours). Hearing sensitivity was assessed using auditory brainstem responses (ABR) before and 12 days after noise exposure. Pharmacokinetic studies investigated ADAC concentrations in plasma after systemic (intravenous) administration[1].

Cas No.

96760-69-9

分子式

C28H32N8O6

分子量

576.614

别名

ADAC

储存和溶解度

DMSO:31.25 mg/mL (54.20 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years