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Tecadenoson
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tecadenoson图片
CAS NO:204512-90-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CVT-510
产品介绍
TecadeNOSon 是 A1 腺苷受体的选择性激动剂。

产品描述

Tecadenoson is a selective agonist of A1 adenosine receptor.

体外活性

Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that induces equal prolongation of S-H interval (~10?ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance [1].

体内活性

Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) [1][2].

Cas No.

204512-90-3

分子式

C14H19N5O5

分子量

337.33

别名

CVT-510

储存和溶解度

DMSO:155 mg/mL (459.49 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years