您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > TABERSONINE HYDROCHLORIDE
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TABERSONINE HYDROCHLORIDE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TABERSONINE HYDROCHLORIDE图片
CAS NO:29479-00-3
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
它波宁盐酸盐
水甘草碱盐酸盐
产品介绍
Tabersonine hydrochloride 是分离自蔷薇中的一种吲哚类生物碱,具有抗炎活性,可用于 ALI/ARDS 的研究。Tabersonine 能破坏 Aβ(1-42) 的聚合和改善 Aβ 聚集诱导的细胞毒性。

产品描述

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

体内活性

TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1].

Cas No.

29479-00-3

分子式

C21H25ClN2O2

分子量

372.89

别名

它波宁盐酸盐;水甘草碱盐酸盐

储存和溶解度

DMSO:40 mg/mL (107.27 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years