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ARN2966
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ARN2966图片
CAS NO:102212-26-0
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ARN2966 是高效的,针对APP表达的转录后调节剂,能够抑制APP的表达从而使Aβ的量降低。

产品描述

ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.

体外活性

ARN2966 reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. ARN2966?also reduces?secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively.

体内活性

In vivo,ARN2966? reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APPSWPS1dE9 transgenic mouse model of Alzheimer's disease.?It also improves novel object memory as well as spatial memory in the radial arm maze in APPSWPS1dE9 transgenic mice.

Cas No.

102212-26-0

分子式

C12H12N2O

分子量

200.24

储存和溶解度

DMSO:43.4 mg/mL (216.74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years