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Porcine dynorphin A(1-13)acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
Porcine dynorphin A(1-13) acetate(72957-38-1 free base)
Dynorphin A Porcine Fragment 1-13 acetate
产品介绍
Porcine dynorphin A(1-13) acetate(72957-38-1 free base) 是一种有效的内源性 κ opioid受体激动剂,在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加,类似于急性 NMDA 治疗所见的增加。

产品描述

Porcine dynorphin A(1-13) acetate is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment.

体内活性

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

Cas No.

TP1179L

分子式

C77H130N24O17

分子量

1664

别名

Porcine dynorphin A(1-13) acetate(72957-38-1 free base);Dynorphin A Porcine Fragment 1-13 acetate

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years