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SNC 80
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SNC 80图片
CAS NO:156727-74-1
包装与价格:
包装价格(元)
5 mg电议
25 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
SNC80
NIH 10815
Snc-80
产品介绍
SNC80 是有效的,高度选择性的非肽类 δ 阿片 (δ-opioid) 受体激动剂,Ki 为1.78 nM,IC50 为 2.73 nM。SNC80 还以 EC50 为 52.8 nM 来选择性激活 HEK293 细胞中的 μ-δ 异聚体。SNC80 具有抗伤害性,抗痛觉过敏和抗抑郁样作用,并可用于多种头痛症的研究。

产品描述

SNC80 is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.

体外活性

SNC80 selectively activates μ-δ heteromer in HEK293 cells, EC50 = 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors [4].

体内活性

SNC80 (10 mg/kg; intraperitoneal injection; once) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan in C57BL6/J mice [1].

Cas No.

156727-74-1

分子式

C28H39N3O2

分子量

449.63

别名

SNC80;NIH 10815;Snc-80

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years