DMCM hydrochloride 是一种苯二氮杂 (benzodiazepine) 非选择性全反向激动剂。DMCM 对人重组 GABAA αxβ3γ2 受体亚型具有亲和力,对 α1,α2,α3 和 α5 受体的 Ki 值分别为 10 nM,13 nM,7.5 nM,2.2 nM。
产品描述
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
体内活性
DMCM has potent convulsant, proconvulsant and anxiogenic properties in vivo. DMCM (20-60 mg/kg; i.p.) produces modest anxiolytic-like effects in γ2I77 mice[2].
Cas No.
1215833-62-7
分子式
C17H19ClN2O4
分子量
350.80
储存和溶解度
H2O:22.5mg/mL (64.1mM),Need ultrasonic
DMSO:9mg/mL (25.7mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years