Lotilaner 是杀寄生虫剂，是非竞争性的昆虫GABACl受体拮抗剂，对果蝇 GABA 受体的IC50值为 23.84 nM。对家犬的 GABAA 无明显作用。

Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA receptor). It also has no effect on a dog GABAA receptor.

Lotilaner displays IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively.

1369852-71-0

C20H14Cl3F6N3O3S

596.76

DMSO:≥ 150 mg/mL (251.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years