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Isoguvacine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isoguvacine hydrochloride图片
CAS NO:68547-97-7
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
异四氢烟酸
产品介绍
Isoguvacine hydrochloride 是 GABA 受体激动剂。它与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。

产品描述

Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.

体外活性

Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events[2]. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus[3].

Cas No.

68547-97-7

分子式

C6H10ClNO2

分子量

163.6

别名

1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride;异四氢烟酸

储存和溶解度

H2O:90 mg/mL (550.12 mM)
DMSO:20 mg/mL (122.25 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years