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ONO-8590580
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONO-8590580图片
CAS NO:1802661-73-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CS-2894
产品介绍
ONO-8590580 是一种 GABAA α5 负变构调节剂。

产品描述

ONO-8590580 is a negative allosteric modulator of GABAA α5.

体内活性

The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data shows that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without an anxiogenic or proconvulsant risk.

Cas No.

1802661-73-9

分子式

C21H21FN6

分子量

376.43

别名

CS-2894

储存和溶解度

DMSO:60 mg/mL (159.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years