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Tiagabine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tiagabine hydrochloride图片
CAS NO:145821-59-6
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NO328 hydrochloride
Gabitril hydrochloride
Gabitril
盐酸噻加宾
NO050328 hydrochloride
TGB hydrochloride
产品介绍
Tiagabine hydrochloride 是具有抗惊厥特性的选择性GABA 再摄取抑制剂,在突触体、神经元和神经胶质中,能够抑制 [3H]GABA 的重摄取,IC50值分别为 67、446 和 182 nM。

产品描述

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

体外活性

Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[4].

体内活性

Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].

Cas No.

145821-59-6

分子式

C20H26ClNO2S2

分子量

412.0

别名

NO328 hydrochloride;Gabitril hydrochloride;Gabitril;盐酸噻加宾;NO050328 hydrochloride;TGB hydrochloride

储存和溶解度

DMSO:41.2 mg/mL (100 mM)
H2O:20.6 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years