LY377604 is a human β3-adrenergic receptor agonist (EC50: 2.4 nM). It also a β1- and β2-adrenergic receptor antagonist.

LY377604 induces a maximal increase in cyclic adenosine monophosphate (cAMP) levels but does not stimulate cAMP accumulation in CHO cells transfected with either the human β1 adrenergic receptor or the human β2 adrenergic receptor.

This is observed as a decrease in the respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats. Administration of LY377604 to male Long-Evans rats fed a caloric dense diet causes stimulation of lipid utilization.

204592-94-9

C31H32N4O4

524.61

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years