JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).

JNJ-46778212 increases NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. JNJ-46778212 displays excellent CNS penetration, in oral brain/plasma studies[1]. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.

1363281-27-9

C20H17FN2O3

352.36

VU 0409551

DMSO:125 mg/mL (354.75 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years