M77976 is the potential for the research of obesity and diabetes. M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4) (IC50: 648 μM).

M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4. M77976 binds to the ATP-binding pocket of PDK4 and induces local conformational changes with complete disordering of the ATP lid.

394237-61-7

C17H16N2O3

296.32

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years