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NS 1209
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS 1209图片
CAS NO:205645-02-9
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议

产品名称
SPD 502
产品介绍
NS 1209 是一种 AMPA 受体拮抗剂。

产品描述

NS1209 is a AMPA receptor antagonist.

体内活性

NS1209 could be safely administered to rats undergoing electrically induced SE at doses up to 50 mg/kg followed by intravenous infusion of 5 mg/kg for up to 24h. NS1209 administered as a bolus dose of 10-50 mg/kg (i.p. or i.v.) followed by infusion of 4 or 5 mg/kg h (i.v.) for 2-24h effectively discontinued electrically induced SE in all animals within 30-60 min, and there was no recurrence of SE after a 24-h infusion. Kainate-induced SE was similarly blocked by 10 or 30 mg/kg NS1209 (i.v.). To compare the efficacy and neuroprotective effects of NS1209 with those of diazepam (DZP), one group of rats received DZP (20 mg/kg, i.p. and another dose of 10 mg/kg 6h later). By using the administration protocols described, the anticonvulsant effect of NS1209 was faster and more complete than that of DZP. NS1209 treatment (20 mg/kg bolus followed by 5 mg/kg h infusion for 24 h) was neuroprotective against SE-induced hippocampal neurodegeneration, but to a lesser extent than DZP.

Cas No.

205645-02-9

分子式

C24H27N4NaO7S

分子量

538.55

别名

SPD 502

储存和溶解度

DMSO:Limited Solubility
Powder: -20°C for 3 years
In solvent: -80°C for 2 years