VU0483605 是一种有效的特异性 mGluR1 正变构调节剂，对人和大鼠的 EC50 分别为 390 和 356 nM。

VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.

VU0483605 shows excellent mGlu1 PAM activity at both human and rat (pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM)[1].

1623101-11-0

C20H10Cl3N3O3

446.67

DMSO:95 mg/mL (212.68 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years