AMN082 是mGluR7选择性激动剂，口服有活性，能够透过血脑屏障，可通过跨膜区的变构位点直接激活受体信号。在表达 mGluR7 的转染哺乳动物细胞上，它能够有效抑制 cAMP 积累并刺激 GTPγS 结合。它能够选择性针对 mGluR 的其他亚型及选择性离子型谷氨酸受体。具有抗抑郁活性。

AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.

MN082 attenuated the development and expression of cocaine and morphine sensitization, and the reciprocal cross-sensitization via a mechanism that involves mGluR7s in mice.

83027-13-8

C28H28N2

392.54

AMN082

DMSO:3.93 mg/ml (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years