VU0650786 是能透过中枢神经系统的，选择性谷氨酸受体亚型 3 的一种负变构调节剂，IC50值为 392 nM，有抗抑郁和抗焦虑活性。

VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.

1809085-30-0

C18H15ClFN5O2

387.8

H2O:insoluble
DMSO:240 mg/mL (618.88 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years