MMPIP hydrochloride 是变构 mGluR7 的选择性拮抗剂。 MMPIP hydrochloride 可用于研究 mGluR7 对中枢神经系统功能的作用。

MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.

In CHO cells coexpressing rat mGluR7 with Gα15, MMPIP hydrochloride inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca2+ mobilization with an IC50 of 26 nM. MMPIP hydrochloride also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC50 of 610 nM. MMPIP hydrochloride inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing rat mGluR7[1].

MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. MMPIP hydrochloride (10 mg/kg; i.p.) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy. MMPIP hydrochloride (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control)[2].

1215566-78-1

C19H16ClN3O3

369.81

MMPIP hydrochloride (479077-02-6 Free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years