VU 29 是代谢型谷氨酸 5(mGlu5)受体的正变构调节剂，对 rmGluR5 的EC50为 9 nM，Ki为 244 nM。相对于其他亚型，它对 mGluR5 具有选择性，对rmGluR1/rmGluR2和hmGluR4的EC50分别为557 nM/1.5 μM和 154 nM。

VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).

890764-36-0

C22H16N4O3

384.39

VU 29

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years