Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.

Dexpramipexole has neuroprotective effects. Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

104632-28-2

C10H17N3S

211.33

R-(+)-Pramipexole;(R)-Pramipexole;右旋普拉克索;KNS-760704

DMSO:10 mg/mL (47.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years