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MPTP hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MPTP hydrochloride图片
CAS NO:23007-85-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MPTP-hydrochloride
产品介绍
MPTP hydrochloride 是 MPPp 的前体,它对多巴胺能神经元有毒并导致帕金森症。可以诱导凋亡作用。

产品描述

MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.

体外活性

Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].

体内活性

The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].

Cas No.

23007-85-4

分子式

C12H16ClN

分子量

209.72

别名

MPTP-hydrochloride

储存和溶解度

DMSO:12 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years