Bromocriptine mesylate 是一种有效的多巴胺受体激动剂，以最高的亲和力结合 D2 受体，Ki 为 2.5 nM。

Bromocriptine is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)

The ergot alkaloid bromocriptine (BKT) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (NOS) (IC50 = 10 +/- 2 microM) whereas it was poorly active towards inducible macrophage NOS (IC50 >100 microM). BKT affects the activation of NOS by calmodulin, as it not only inhibits L-arginine oxidation to NO and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by neuronal NOS. These results suggest that BKT could exert some of its therapeutic effects by interfering with the NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues.

22260-51-1

C33H44BrN5O8S

750.71

CB-154;甲磺酸溴隐亭

DMSO:30 mg/mL (39.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years