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Buflomedil hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Buflomedil hydrochloride图片
CAS NO:35543-24-9
包装与价格:
包装价格(元)
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
盐酸丁咯地尔
丁咯地尔盐酸盐
Fonzylane
Buflomedil HCl
Loftyl
产品介绍
Buflomedil hydrochloride 是一种血管扩张剂,可用于外周动脉疾病引发的一系列症状。

产品描述

Buflomedil hydrochloride, a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.

体外活性

Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells.

Cas No.

35543-24-9

分子式

C17H26ClNO4

分子量

343.85

别名

盐酸丁咯地尔;丁咯地尔盐酸盐;Fonzylane;Buflomedil HCl;Loftyl

储存和溶解度

H2O:63 mg/mL (183.2 mM)
Ethanol:7 mg/mL (20.35 mM)
DMSO:29 mg/mL (84.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years