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Amezinium methylsulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amezinium methylsulfate图片
CAS NO:30578-37-1
包装与价格:
包装价格(元)
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Lu-1631
Amezinium metilsulfate
Amezinium (methylsulfate)
甲磺美嗪
产品介绍
Amezinium metilsulfate 具有多种机制,包括刺激 α 和 β-1 受体以及抑制去甲肾上腺素和酪胺的摄取。

产品描述

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.

体内活性

In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %) [1]. The reduction ratio of FTBF was significantly increased by amezimium [placebo, 75.9%; amezinium, 85.1%; midodrine, 78.1%]. The infusion rate of noradrenaline producing a half-maximum venoconstriction was significantly decreased by amezinium (placebo, 40.6 ng/min; amezinium, 21.0 ng/min) [2].

Cas No.

30578-37-1

分子式

C12H15N3O5S

分子量

313.33

别名

Lu-1631;Amezinium metilsulfate;Amezinium (methylsulfate);甲磺美嗪

储存和溶解度

DMSO:31.3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years