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Nadolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nadolol图片
CAS NO:42200-33-9
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品名称
Corgard
Anabet
苯甲丁氮酮
SQ11725
纳多洛尔
Solgol
产品介绍
Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-Adrenergic Receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。

产品描述

Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.

Cas No.

42200-33-9

分子式

C17H27NO4

分子量

309.406

别名

Corgard;Anabet;苯甲丁氮酮;SQ11725;纳多洛尔;Solgol

储存和溶解度

DMSO:197.2 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years