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NKP608
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NKP608图片
CAS NO:177707-12-9
包装:50 mg
市场价:12328元

产品介绍

产品描述

NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.

体外活性

The binding of NKP608 to the bovine retina was characterized by an IC50 of 2.6 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC50 values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13 and 27 nM in gerbil midbrain and rat striatum, respectively.

体内活性

Using the hindfoot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID50: 0.23 mg/kg, 2 h pretreatment), supporting a central activity of NKP608.

Cas No.

177707-12-9

分子式

C31H24ClF6N3O2

分子量

619.99

储存和溶解度

H2O:Insoluble
DMSO:100 mg/mL (161.30 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years