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Tranylcypromine hemisulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tranylcypromine hemisulfate图片
CAS NO:13492-01-8
包装与价格:
包装价格(元)
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
反苯环丙胺半硫酸盐
Tranylcypromine Sulfate
Tranylcypromine (hemisulfate)
产品介绍
Tranylcypromine hemisulfate是单胺氧化酶 (MAO) 和赖氨酸特异性去甲基化酶 1 (LSD1) 的抑制剂,可用于研究抑郁症和子宫内膜异位症。

产品描述

Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.

体内活性

Tranylcypromine-induced transcriptional and epigenetic regulation modulated RGC survival via the promotion of p38 MAPKγ activity. Therefore, pharmacologic treatments that suppress LSD1 activity may be a novel therapeutic strategy that can be used to treat neurodegenerative diseases[1].

动物实验

The authors evaluated whether tranylcypromine contributes to neuronal survival following stress-induced damage using primary cultured rat RGCs and in vivo N-methyl-D-aspartate (NMDA)-induced excitotoxicity.?Additionally, the molecules associated with tranylcypromine treatment were assessed by microarray and immunoblot analysis[1].

Cas No.

13492-01-8

分子式

C18H24N2O4S

分子量

364.46

别名

反苯环丙胺半硫酸盐;Tranylcypromine Sulfate;Tranylcypromine (hemisulfate)

储存和溶解度

DMSO:5 mg/mL (27.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years