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PF-06751979
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06751979图片
CAS NO:1818339-66-0
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).

体外活性

PF-06751979 shows improved selectivity over BACE2 (IC50=194 nM) in binding (27-fold) relative to the literature examples and across multiple chemical series in BACE1 program.

体内活性

PF-06751979 displays excellent brain penetration, potent in vivo efficacy, and broad selectivity over related aspartyl proteases including BACE2. Acute administration of PF-06751979 yields a robust dose-responsive and time-dependent reduction of cerebral spinal fluid (CSF) Aβx-40 with peak inhibition at 3 h of >77%.[1].

Cas No.

1818339-66-0

分子式

C18H19F2N5O3S2

分子量

455.5

储存和溶解度

Ethanol:50 mg/mL (109.77 mM),Need ultrasonic
DMSO:150 mg/mL (329.31 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years