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Metoclopramide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metoclopramide图片
CAS NO:364-62-5
包装:25 mg
市场价:685元

产品名称
胃复安
甲氧氯普胺
5-Chloro-2-methoxyprocainamide
产品介绍
Metoclopramide 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。

产品描述

Metoclopramide is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

Cas No.

364-62-5

分子式

C14H22ClN3O2

分子量

299.8

别名

胃复安;甲氧氯普胺;5-Chloro-2-methoxyprocainamide

储存和溶解度

DMSO:41 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years