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Tandospirone citrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tandospirone citrate图片
CAS NO:112457-95-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
坦度螺酮柠檬酸盐
枸橼酸坦度螺酮
SM-3997 citrate
产品介绍
Tandospirone citrate 是一种选择性5-HT1A 受体激动剂,Ki为27 nM。

产品描述

Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)

体内活性

Improvements in total abdominal scores were significantly larger with tandospirone than placebo at weeks 1, 2, and 4.?Significantly greater improvements in the tandospirone group were observed in upper abdominal pain (P=0.02) and discomfort (P=0.002) at week 4.?The proportion of responders was significantly greater in the active treatment arm at weeks 3 (P=0.017) and 4 (P=0.0016).?Significant improvements in STAI (P<0.0001) were reported in both arms, as well as in the majority of questions in the SF-8 (P=0.04).?No serious adverse events were reported, with similar rates in both study arms[1]

细胞实验

In this double-blind, placebo-controlled, multicenter study, FD patients were randomized to treatment with 10 mg t.i.d. tandospirone citrate or to placebo for 4 weeks. The primary end point was change in abdominal symptom scores. The difference in the proportion of responders (a total abdominal symptom score of 0 or 1) was also assessed. The quality-of-life questionnaire, the SF-8, and a psychological test questionnaire, the State-Trait Anxiety Inventory (STAI), were completed at baseline and at weekly intervals[1]

Cas No.

112457-95-1

分子式

C27H37N5O9

分子量

575.619

别名

坦度螺酮柠檬酸盐;枸橼酸坦度螺酮;SM-3997 citrate

储存和溶解度

H2O:10.4 mg/mL (18.07 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years