JNJ-61432059 是具有口服活性的选择性AMPAR负向调节剂，对 GluA1/γ-8 的pIC50值为9.7。

JNJ-61432059 is an oral active and selective negative modulator of TARP γ-8 Selective AMPAR(pIC50: 9.7).

In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.

2035814-50-5

C25H22FN5O2

443.47

DMSO:42.5 mg/mL (95.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years