产品描述
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP .
体内活性
NKH477 (p.o.; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.
Cas No.
138605-00-2
分子式
C27H44ClNO8
分子量
546.09
别名
Colforsin dapropate hydrochloride
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years