D-AP5 是一种选择性和竞争性NMDA受体拮抗剂，Kd为 1.4 μM。D-AP5 抑制 NMDA 受体的谷氨酸结合位点。

D-AP5 is a NMDA receptor antagonist.

D-AP5 is an NMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.

79055-68-8

C5H12NO5P

197.13

D-APV;D-2-Amino-5-phosphonovaleric acid;(R)-(-)-2-氨基-5-膦酰戊酸

H2O:27.78 mg/mL (140.92 mM),Need ultrasonic
Ethanol:< 1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years