S 18986 是一种选择性的、口服活性的、脑渗透性的 AMPA-type 受体正向变构调节剂。S 18986 显示啮齿动物具有增强认知能力的特性。S 18986 激活大鼠海马去甲肾上腺素和乙酰胆碱的释放，增强大鼠在物体识别实验中的记忆。

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

S 18986 displays antiamnesic properties in middle-aged rodents in spatial memory models. S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 (5-50 mg/kg; i.p.) obviously enhances both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation [1].

175340-20-2

C10H12N2O2S

224.28

DMSO:20 mg/ml(89.17 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years