PoMAGLumetad methionil hydrochloride (LY2140023 hydrochloride) 是一种选择性 mGlu2/3 受体激动剂 LY404039 的蛋氨酸前药，具有口服活性。PoMAGLumetad methionil hydrochloride 可用于精神分裂症的研究。

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM. LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

635318-26-2

C12H19ClN2O7S2

402.87

LY2140023 hydrochloride

DMSO:22.5mg/mL (55.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years