ML289是一种高效、选择性的，可透过血脑屏障的 mGlu3 (IC50=0.66 μM) 负变构调节剂。ML289 的选择性是 mGlu2 的 15 倍，对 mGlu5 无活性。

ML289 is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5.

ML289 (VU0463597) is a CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) negative allosteric modulator probe[1].

1382481-79-9

C22H23NO3

349.42

VU0463597

DMSO:225mg/mL (643.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years