Caroverine hydrochloride 是竞争性可逆的NMDA和AMPA谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。

Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and can be used for the research of inner ear tinnitus.

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta[1].Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[2]

55750-05-5

C22H28ClN3O2

401.94

Caroverine HCL

DMSO:100 mg/mL (248.80 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years