Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶和丁酰胆碱酯酶具有抗胆碱酯酶的特性，IC50分别为 0.66 μM 和 7.39 μM。它还抑制组蛋白乙酰转移酶和 p300/CPB 相关因子，具有抗炎和抗癌活性。

Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.

Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells. ?Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.

Garcinol?induces significant inhibition of tumor growth.

78824-30-3

C38H50O6

602.8

DMSO:20 mg/mL (33.18 mM),Need ultrasonic and warming
Ethanol:20 mg/mL (33.18 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years